Title
Role of IκB kinase β in regulating the remodeling of the CARMA1-Bcl10-MALT1 complex
Publication Date
6-2-2018
Publication Name
Biochemical and Biophysical Research Communications
Document Type
Article
Volume
500
Issue
2
First Page
268
Last Page
274
DOI
10.1016/j.bbrc.2018.04.057
Abstract
© 2018 Elsevier Inc. The current work investigates the notion that inducible clustering of signaling mediators of the IKK pathway is important for platelet activation. Thus, while the CARMA1, Bcl10, and MALT1 (CBM) complex is essential for triggering IKK/NF-κB activation upon platelet stimulation, the signals that elicit its formation and downstream effector activation remain elusive. We demonstrate herein that IKKβ is involved in membrane fusion, and serves as a critical protein kinase required for initial formation and the regulation of the CARMA1/MALT1/Bcl10/CBM complex in platelets. We also show that IKKβ regulates these processes via modulation of phosphorylation of Bcl10 and IKKγ polyubiquitination. Collectively, our data demonstrate that IKKβ regulates membrane fusion and the remodeling of the CBM complex formation.