Title
Looking back, looking forward at halogen bonding in drug discovery
Publication Date
9-1-2017
Publication Name
Molecules
Document Type
Article
Volume
22
Issue
9
DOI
10.3390/molecules22091397
Abstract
© 2017 by the authors. Licensee MDPI. Halogen bonding has emerged at the forefront of advances in improving ligand: receptor interactions. In particular the newfound ability of this extant non-covalent-bonding phenomena has revolutionized computational approaches to drug discovery while simultaneously reenergizing synthetic approaches to the field. Here we survey, via examples of classical applications involving halogen atoms in pharmaceutical compounds and their biological hosts, the unique advantages that halogen atoms offer as both Lewis acids and Lewis bases.
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