Date of Award

2024-12-01

Degree Name

Master of Science

Department

Electrical and Computer Engineering

Advisor(s)

Miguel Velez -Reyes

Abstract

Iron deficiency (ID) and iron deficiency anemia (IDA) are widespread nutritional issues, affecting millions globally. Conventional iron supplements often suffer from low absorption rates and gastrointestinal side effects. We investigated β-glucan derivatives as potential carriers to enhance iron absorption and mitigate these drawbacks. This study explored a novel β-glucan-based carrier system loaded with ferrous sulfate heptahydrate. In-vitro studies demonstrated sustained iron stability for over six hours in simulated gastric fluids due to the carrier's affinity for stomach mucin. Particle size analysis and scanning electron microscopy (SEM) images confirmed this specific binding. Additionally, drug release studies revealed a pH-dependent release profile, favoring iron delivery within the stomach. Oral administration of β-glucan-iron complexes demonstrated improved overall efficacy with minimal adverse effects, suggesting a promising strategy for improved iron supplementation. This research highlights the potential of β-glucan derivatives as carriers for oral iron delivery, offering enhanced absorption and potentially reducing gastrointestinal side effects. Further refinement holds promise for transitioning various injectable iron medications to a more patient-friendly oral form.

Language

en

Provenance

Recieved from ProQuest

File Size

127 p.

File Format

application/pdf

Rights Holder

MILA BISWAS

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