Date of Award
2020-01-01
Degree Name
Master of Science
Department
Physics
Advisor(s)
Felicia S. Manciu
Abstract
To accurately identify and measure the concentrations of dopamine (DA) and serotonin (5-HT) in mixtures of these neurotransmitters without labeling, a comprehensive, comparative computational and Raman experimental analysis is provided. While the distinction between these two analytes may be accomplished for concentrations in the millimolar range of these mixtures, their accurate quantification remains unattainable. As shown for the first time in this study, potential creation of a new composite resulting from their interactions with each other could be a reason for this lack of quantification.
Although this new hydrogen-bonded complex greatly complicates future analyte differentiation and quantification at concentrations typical of clinical thresholds (i.e. nanomolar concentrations), it may also create new opportunities for use in drug distribution and pharmaceutical investigations. This remark not only is based on the chemical interactions studied here by both theoretical and experimental viewpoints but also on the biological proximity of these neurotransmitters. This work provides a significant, complementary contribution to a deeper understanding of neuronal processes and potential future creation of label-free biosensors.
Language
en
Provenance
Received from ProQuest
Copyright Date
2020-05
File Size
42 pages
File Format
application/pdf
Rights Holder
Jose A Guerrero
Recommended Citation
Guerrero, Jose A., "Comparative Experimental And Theoretical Study Of Dopamine And Serotonin Interaction" (2020). Open Access Theses & Dissertations. 2975.
https://scholarworks.utep.edu/open_etd/2975