Title
The footprint of androgen sensitive serine protease (TMPRSS2) in gender mortality with COVID-19
Publication Date
5-2020
Publication Name
Immunopathologia Persa
Document Type
Article
Abstract
Male gender is an obvious risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mortality rate is higher in men than women. Undoubtedly, gender-related behavioral factors, such as higher amounts of smoking, alcohol consumption, and biological differences in immune systems could make males more vulnerable. The role of androgen-responsive elements (AREs) of transmembrane serine proteases type II (TMPRSS2) gene as one of the major players of male dominancy in severe COVID-19 infection has been under appreciated and needs to be clarified.
Volume
6
Issue
2
DOI
https://doi.org/10.34172/ipp.2020.27
Comments
Zununi Vahed S., Ghiyasvand S., Tolouian R., Noshad H., Tolouian A, Mohajel Shoja M., Ardalan M. (2020). The footprint of androgen sensitive serine protease (TMPRSS2) in gender mortality with COVID-19. Immunopathologia Persa, 6(2): e27. https://doi.org/10.34172/ipp.2020.27