Date of Award


Degree Name

Master of Science


Manufacturing Engineering


Tzu-Liang (Bill) Tseng

Second Advisor

Namsoo (Peter) Kim


Research is conducted to create dissolving collagen microneedles and to optimize the parameters for close to perfect dimension microneedles. A collagen microneedle patch has been developed with a micro-manufacturing process (micro-molding process). The collagen microneedles, varying in length from 300 to 600-μm may reach different targeted layers of the skin depending on the application. As the microneedles penetrate the skin they dissolve, delivering collagen through the epidermis. Such addition of collagen directly to the dermis layers allows it to be absorbed, increasing skin's strength and resilience, since it is one of the natural components of the younger looking skin. This process of collagen delivery system is painless, hygienic and easy to use. The research included the preparation of various concentrations and modification in various parameters in order to optimize the process of the microneedle patch preparation. Data is collected from various experimental trials and statistical analysis is conducted using Taguchi L9 method. Parameters such as microneedle height, pressure drop, time in the vacuum oven, and concentration are considered and analyzed to check which parameter has the greatest influence in the production of in order to obtain the best microneedle patch. The dissolving collagen microneedle process parameters are optimized for close to perfect dimensions.




Received from ProQuest

File Size

94 pages

File Format


Rights Holder

Abhilash Aditya