Date of Award

2024-08-01

Degree Name

Doctor of Philosophy

Department

Interdisciplinary Health Sciences

Advisor(s)

Gabriel Ibarra-Mejia

Abstract

BACKGROUND: Inflammation is an acute phase response to physiological conditions such as infection, tissue injury, and tissue stress and malfunction (Medzhitov, 2008). Inflammation caused by surgical trauma (tissue injury) elicits a myriad of responses by the patient that is experienced far past the operation. It is estimated that American individuals will undergo nine surgeries throughout an 85 year lifespan (Lee & Gawande, 2008). Focus on surgical recovery modalities has grown over the past few decades. The use of compression garments (CG+) following surgery has been shown to be successful in preventing deep vein thrombosis, pulmonary embolisms, as well as aiding in human performance and recovery, but has yet to be established as an effective strategy that alters physiological activity in inflammatory biomarkers such as Interleukin-6 (IL-6), C-Reactive Protein (CRP), and the Erythrocyte Sedimentation Rate (ESR). PURPOSE: The primary purpose of this study was to investigate the efficacy of CG use to impact the expression of inflammatory biomarkers IL- 6, CRP, and the ESR following cosmetic surgery. The secondary aim was to investigate CGs effect on self-reported recovery symptoms of pain and loss of physical function. METHODS: Healthy normal, overweight, and obese (BMI 18.5-37) male and female individuals aged â?¥18 years were randomized into either an INTERVENTION (Group 1: CG+) or a CONTROL (Group 2: CG-). All subjects undergoing cosmetic surgery completed an interview for study inclusion, physical and health history, complete blood work up (IL-6, CRP, ESR), and measures of self-reported pain and loss of function. Factors of interest were measured pre and at 24-, 48-, and 72-hours following cosmetic surgery. RESULTS: CG group demonstrated a significant reduction in IL-6 at 24 hours (p=0.02), CRP at 48 hours (p=0.04), and work/exercise related activity at 24- (p=0.02), 48- (p=0.02), and 72 hours (p=0.01). There were no significant differences between groups for pain, overall activity, sedentary activity, or for ambulatory activity at all timepoints. CONCLUSION: CGs decrease acute postoperative inflammation and improves short-term postoperative loss of function. Compression garments could be considered as an alternative therapeutic strategy to lessen inflammatory biomarkers expression and loss of function in patients undergoing cosmetic surgery.

Language

en

Provenance

Received from ProQuest

File Size

80 p.

File Format

application/pdf

Rights Holder

Michael James Sanchez

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Included in

Surgery Commons

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