Disability and self-reported adverse drug events among patients with chronic diseases
Drugs and Therapy Perspectives
© 2020, Springer Nature Switzerland AG. Objective: Very few studies have examined the association between self-reported adverse drug events (ADEs) and the presence of disability in patients with chronic diseases. The purpose of this study was to investigate the relationship between disability and self-reported ADEs in a population with chronic diseases in the community setting in Korea. Methods: Data were obtained from the Korean Health Panel from 2014 to 2016, from which 5382 adults aged ≥ 30 years who received any drug to treat a chronic disease were selected. The dependent variable was defined as a self-reported ADE related to a chronic-disease drug. Disability was measured by self-reported vision problems, hearing problems, cognitive impairment, chewing problems, and activity limitation. The data were analyzed using panel logistic regression. Results: In 2016, 5.07% of participants self-reported an ADE related to a chronic-disease drug. The likelihood of a patient self-reporting an ADE depended on various sociodemographic factors, health status including disabilities, and polypharmacy. Specific risk factors for ADEs included age, vision problems, chewing problems, activity limitations, and polypharmacy. Subgroup analyses showed that the risk factors of hypertension, diabetes, and hyperlipidemia had slightly different effects on self-reporting of ADEs. Conclusions: Disabilities, such as vision problems, chewing problems, and activity limitation, were significantly related to self-reported ADEs in chronic-disease patients in the community setting.