Date of Award


Degree Name

Doctor of Philosophy


Biological Sciences


Arshad M. Khan


The hypothalamus is a region of the brain with exceptionally high anatomical, chemical, and functional diversity. It regulates homeostatic functions and a number of motivated behaviors impacting homeostasis, such as ingestion and reproduction; it also serves as a point of connection between the forebrain and hindbrain. An improved understanding of the chemical anatomy of this area would benefit scientists working in many neuroscientific disciplines. The work described herein contributes to a chemoarchitectural atlas of the rat hypothalamus, which will include data on the distribution of various hypothalamic neurotransmitters, and on their co-localizations and synaptic interactions. Importantly, the methodology used to generate this contribution to the atlas has been rigorously documented and discussed. Additionally, new methodologies for easily transferring mapped data between atlases have been explored, in order that the new chemoarchitectural atlas may benefit from the decades of behavioral and functional work performed in the rat hypothalamus. Finally, the beginnings of a comprehensive analysis of the differences between major brain atlases based on stereotaxic coordinates has been created.




Received from ProQuest

File Size

249 pages

File Format


Rights Holder

Claire Eugenia Wells