Date of Award
Master of Science
In high-dimensional gene expression data analysis, the accuracy and reliability of cancer classification and selection of important genes play a very crucial role. To identify these important genes and predict future outcomes (tumor vs. non-tumor), various methods have been proposed in the literature. But only few of them take into account correlation patterns and grouping effects among the genes. In this article, we propose a rank-based modification of the popular penalized logistic regression procedure based on a combination of l1 and l2 penalties capable of handling possible correlation among genes in different groups. While the l1 penalty maintains sparsity, the l2 penalty induces smoothness based on the information from the Laplacian matrix, which represents the correlation pattern among genes. We combined logistic regression with the BH-FDR (Benjamini and Hochberg false discovery rate) screening procedure and a newly developed rank-based selection method to come up with an optimal model retaining the important genes. Through simulation studies and real-world application to high-dimensional colon cancer gene expression data, we demonstrated that the proposed rank-based method outperforms such currently popular methods as lasso, adaptive lasso and elastic net when applied both to gene selection and classification.
Received from ProQuest
Md Showaib Rahman None Sarker
Sarker, Md Showaib Rahman None, "On The Performance Of Variable Selection And Classification Via Rank-Based Classifier" (2019). Open Access Theses & Dissertations. 2010.