Effects of Repeated Nicotine Vapor Exposure and Withdrawal on Somatic Signs, Anxiety-Like Behavior, and Brain Reward Thresholds in Male Sprague Dawley Rats
Experiment 1: This experiment investigated the effects of repeated nicotine vapor exposure on somatic withdrawal signs and anxiety-like behavior in rats. Withdrawal in human users of traditional nicotine products is well described, therefore examining withdrawal behaviors following vapor exposure is a necessary first step for nicotine vapor research. Experiment 2: This experiment investigated the effects of acute and repeated nicotine vapor exposure on brain reward function. More specifically, this experiment assessed the effects of nicotine vapor exposure and withdrawal on ICSS brain reward thresholds in rats. Findings will provide valuable insight on how nicotine vapor can affect the brain reward system.
Martinez, Michelle, "Effects of Repeated Nicotine Vapor Exposure and Withdrawal on Somatic Signs, Anxiety-Like Behavior, and Brain Reward Thresholds in Male Sprague Dawley Rats" (2021). ETD Collection for University of Texas, El Paso. AAI28540885.